Follow this step-by-step checklist to position your startup or business to capture revenue from the emerging agent economy.
Based on: The Next $100B Market: Selling To AI Agents by Greg Isenberg
What if your biggest future customers aren't human? That question might sound like science fiction, but Greg Isenberg — one of the most plugged-in startup thinkers online — is convinced the answer will define the next decade of the internet. And once you see the shift he's describing, you can't unsee it.
Here's the uncomfortable truth: if your website, product, or business was built purely for human visitors, you're already becoming invisible to a growing class of customers. AI agents — personal agents, business agents, autonomous purchasing agents — are beginning to discover, evaluate, transact with, and recommend products and services on behalf of their human owners. They don't read your beautiful landing page copy. They don't watch your demo video. They parse structured data, call APIs, check policy docs, and execute transactions. If your product isn't built for them, they simply move on.
Most founders and business owners haven't even started thinking about this. That's actually good news for you. The infrastructure layer for the agent economy is almost entirely unbuilt. Agent inboxes, agent wallets, agent identity, agent analytics, agent-readable pricing pages — every single category that exists for human users needs to be rebuilt for agents. Greg calls it the machine-to-machine economy, and he says almost nobody is building for it yet.
Imagine having your startup or business fully positioned before the crowd arrives. Your homepage is structured so agents can instantly understand what you do. Your product exposes clean API endpoints and MCP tools agents can invoke. You're optimized for AEO — agent engine optimization — so when one agent asks another what tool to use, your name comes up. You have an agent analytics dashboard telling you which agents visited, what they asked, and where they dropped off. You're not just surviving the AI transition — you're one of the few operators who saw it coming and built for it.
Greg Isenberg has been sounding the alarm on this shift publicly, and this checklist distills his full framework into clear, concrete actions you can start taking today. From auditing your current website for agent readability, to building out capability manifests, to exploring the specific startup ideas Greg identified as highest opportunity — this PDF walks you through every step.
Stop building only for humans. Use this checklist to future-proof your business and get in front of the next $100 billion market before everyone else figures out it exists.
Every checklist item comes with actionable notes to guide you — things like "Don't forget to do this before you start," "Avoid this common mistake," or "Set a reminder for 30 days out." Nothing vague, just clear next steps.
+ 17 more action items inside...
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